![]() Protein metabolism was also impacted, thus returning glutamine and glucogenic amino acids to nascent levels. Atorvastatin restored the levels of ketone bodies, acetoacetate, acetone, and 3-hydroxybutyrate to normal. In another study, 1H NMR-based metabolomics were used to monitor plasma and liver profiles following Atorvastatin treatment. In contrast, estrone, cortisone, proline, cystine, 3-ureidopropionic acid, and histidine were associated with Atorvastatin-induced liver toxicity. In response to treatment, metabolite profiling suggested restoration of “healthy” metabolism. ![]() Metabolic profiling of plasma and tissue (liver, aorta, cardiac muscle, and brain) following oral administration of these drugs was analyzed by MS coupled with multivariate data analysis in rabbit and rat models. Metabolomics has been utilized to explore the therapeutic effect of antilipemic drugs such as Atorvastatin and Simvastatin. Apart from chemical therapeutics and TCM, food itself can exert a hypolipemic effect, i.e., fish oil, Pu-erh tea, Auricularia auricula, and Hawthorn. These antilipemic TCMs can be grouped into three categories: (1) herbs promoting excretions, generally by reducing food retention, enhancing purgative effect, and promoting diuresis and choleresis (2) herbs acting on the cardiovascular system, generally by improved blood circulation (3) herbs that have tonic effect. Interestingly, more than 50 traditional Chinese medicines (TCM) have also been used to treat hyperlipidemia. Rui-Chao Lin, in Advances in Clinical Chemistry, 2014 6.1.2 Antilipemic agent researchĬurrently, statins, fibrates, nicotinic acid, and cholesterol absorption inhibitors remain the main therapeutics to reduce circulating lipids. So the curtain falls on this years’ auricula display and we can now start thinking about next years’ flowers.Hua Chen. The auricula display is now complete and the theatre is displaying pelargoniums. Already we have about 140 different varieties in our collection and we hope to build upon that. Well, it has to be said that five weeks later we are pretty pleased with ourselves! Things have gone so well. The theatre looked its best for all our visitors at all times and we managed an extra week of display. We used a peat free potting mix which hit the spot and having the auriculas here on site at different stages of growth meant it was so simple to replace a fading plant with a fresh. In preparation for growing our own auriculas the gardening team constructed a new greenhouse in autumn last year and it worked as well as we had planned allowing us to control the amount of shade and ventilation for the growing plants. Circumstances change and this year we went solo, hoping that our visitors wouldn’t see a dramatic decline in the standard of display! We brought over a collection as they came into flower and returned them when we had finished with them, just like a library book. ![]() Calke Abbey has the only original auricula theatre in the country.įor decades the Calke Gardeners worked with a nursery who would supply us with the auriculas to stock the theatre. ![]() As tastes changed they fell out of fashion and houses removed the theatres. In large country houses it was the fad in the 18th century to have auricula theatres to display these flowers at their best.
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